Epigenetic Age Acceleration and Cognitive Decline: A Twin Study.

ABSTRACT:

Background

Little is known about the role of DNA methylation (DNAm) epigenetic age acceleration in cognitive decline. Using a twin study design, we examined whether DNAm age acceleration is related to cognitive decline measured longitudinally in persons without a clinical diagnosis of dementia.

Methods

We studied 266 paired male twins (133 pairs) with a mean age of 56 years at baseline. Of these, 114 paired twins returned for a follow-up after an average of 11.5 years. We obtained 6 indices of DNAm age acceleration based on epigenome-wide data from peripheral blood lymphocytes. At both baseline and follow-up, we administered a battery of cognitive measures and constructed 2 composite scores, one for executive function and one for memory function. We fitted multivariable mixe

SUBMITTER: Vaccarino V 

PROVIDER: S-EPMC8436988 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature