The Autophagy Inducer Spermidine Protects Against Metabolic Dysfunction During Overnutrition.

ABSTRACT: Autophagy, a process catabolizing intracellular components to maintain energy homeostasis, impacts aging and metabolism. Spermidine, a natural polyamine and autophagy activator, extends life span across a variety of species, including mice. In addition to protecting cardiac and liver tissue, spermidine also affects adipose tissue through unexplored mechanisms. Here, we examined spermidine in the links between autophagy and systemic metabolism. Consistently, daily injection of spermidine delivered even at late life is sufficient to cause a trend in life-span extension in wild-type mice. We further found that spermidine has minimal metabolic effects in young and old mice under normal nutrition. However, spermidine counteracts high-fat diet (HFD)-induced obesity by increasing lipolysis in vis

SUBMITTER: Liao CY 

PROVIDER: S-EPMC8436989 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature