Slowed Protein Turnover in Aging Drosophila Reflects a Shift in Cellular Priorities.

ABSTRACT: The accumulation of protein aggregates and dysfunctional organelles as organisms age has led to the hypothesis that aging involves general breakdown of protein quality control. We tested this hypothesis using a proteomic and informatic approach in the fruit fly Drosophila melanogaster. Turnover of most proteins was markedly slower in old flies. However, ribosomal and proteasomal proteins maintained high turnover rates, suggesting that the observed slowdowns in protein turnover might not be due to a global failure of quality control. As protein turnover reflects the balance of protein synthesis and degradation, we investigated whether decreases in synthesis or decreases in degradation would best explain the observed slowdowns in protein turnover. We found that while many individual proteins

SUBMITTER: Vincow ES 

PROVIDER: S-EPMC8436993 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature