Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study.

ABSTRACT:

Background

Gait speed is a powerful indicator of health with aging. Potential genetic contributions to gait speed and its decline with aging are not well defined. We determined the heritability of and potential genetic regions underlying change in gait speed using longitudinal data from 2379 individuals belonging to 509 families in the Long Life Family Study (mean age 64 ± 12, range 30-110 years; 45% men).

Methods

Gait speed was measured over 4 m at baseline and follow-up (7 ± 1 years). Quantitative trait linkage analyses were completed using pedigree-based maximum likelihood methods with logarithm of the odds (LOD) scores greater than 3.0, indicating genome-wide significance. We also performed linkage analysis in the top 10% of families contributing to LOD scores to allow f

SUBMITTER: Santanasto AJ 

PROVIDER: S-EPMC8436996 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature