The association between bacteria colonizing the upper respiratory tract and lower respiratory tract infection in young children: a systematic review and meta-analysis.

ABSTRACT:

Background

Bacteria colonizing the upper respiratory tract (URT) of young children play a key role in the pathogenesis of lower respiratory tract infection (LRTI).

Objectives

To systematically review the literature on the association between bacteria colonizing the URT and LRTI among young children.

Data sources

MEDLINE, Academic Search Premier, Africa-Wide Information and CINAHL, Scopus and Web of Science.

Study eligibility criteria

Studies published between 1923 and 2020, investigating URT bacteria from LRTI cases and controls.

Participants

Children under 5 years with and without acute LRTI.

Methods

Three reviewers independently screened titles, abstracts and full texts. Meta-analysis was done using Mantel-Haenszel fixed- or random-effects model

SUBMITTER: Claassen-Weitz S 

PROVIDER: S-EPMC8437050 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature