Epigenome-Wide DNA Methylation and Pesticide Use in the Agricultural Lung Health Study.

ABSTRACT:

Background

Pesticide exposure is associated with many long-term health outcomes; the potential underlying mechanisms are not well established for most associations. Epigenetic modifications, such as DNA methylation, may contribute. Individual pesticides may be associated with specific DNA methylation patterns but no epigenome-wide association study (EWAS) has evaluated methylation in relation to individual pesticides.

Objectives

We conducted an EWAS of DNA methylation in relation to several pesticide active ingredients.

Methods

The Agricultural Lung Health Study is a case-control study of asthma, nested within the Agricultural Health Study. We analyzed blood DNA methylation measured using Illumina's EPIC array in 1,170 male farmers of European ancestry. For pesticides

SUBMITTER: Hoang TT 

PROVIDER: S-EPMC8437246 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature