Defective expansion and function of memory like natural killer cells in HIV+ individuals with latent tuberculosis infection.

ABSTRACT:

Purpose

Tuberculosis (TB) is the leading cause of infectious disease related mortality, and only 10% of the infected individuals develop active disease. The likelihood of progression of latent tuberculosis infection (LTBI) to active TB disease is high in HIV infected individuals. Identification of HIV+ individuals at risk would allow treating targeted population, facilitating completion of therapy for LTBI and prevention of TB development. NK cells have an important role in T cell independent immunity against TB, but the exact role of NK cell subsets in LTBI and HIV is not well characterized.

Methods

In this study, we compared the expansion and function of memory like NK cells from HIV-LTBI+ individuals and treatment naïve HIV+LTBI+ patients in response to Mtb antigens ESAT-

SUBMITTER: Devalraju KP 

PROVIDER: S-EPMC8437280 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature