Insight Into the Potential Value of Gut Microbial Signatures for Prediction of Gestational Anemia.

ABSTRACT: The gut microbiota alternations are associated with gestational anemia (GA); however, limited predictive value for the subsequent incidence of anemia in normal gestational women has been obtained. We sought to rigorously characterise gut dysbiosis in subjects with GA and explored the potential predictive value of novel microbial signatures for the risk of developing GA. A prospective cohort of subjects with GA (n = 156) and healthy control (n = 402), all of whom were free of GA in the second trimester, by 16S rRNA gene sequencing was conducted. Microbial signatures altered dramatically in GA compared with healthy control in the second trimester. Megamonas, Veillonella, and Haemophilus were confirmed to show differential abundances in GA after adjusting for covariates.

SUBMITTER: Wei H 

PROVIDER: S-EPMC8437374 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature