Addressing shortfalls of laboratory HbA_1c using a model that incorporates red cell lifespan.

ABSTRACT: Laboratory HbA_1c does not always predict diabetes complications and our aim was to establish a glycaemic measure that better reflects intracellular glucose exposure in organs susceptible to complications. Six months of continuous glucose monitoring data and concurrent laboratory HbA_1c were evaluated from 51 type 1 diabetes (T1D) and 80 type 2 diabetes (T2D) patients. Red blood cell (RBC) lifespan was estimated using a kinetic model of glucose and HbA_1c, allowing the calculation of person-specific adjusted HbA_1c (aHbA_1c). Median (IQR) RBC lifespan was 100 (86-102) and 100 (83-101) days in T1D and T2D, respectively. The median (IQR) absolute difference between aHbA_1c and laboratory HbA_1c was 3.9 (3.0-14.3) mmol/mol

SUBMITTER: Xu Y 

PROVIDER: S-EPMC8437432 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature