Projected impact of a plant-derived vaccine on the burden of seasonal influenza in Canada.

ABSTRACT:

Objective

The analysis estimates projected population outcomes resulting from the introduction of a plant-derived influenza vaccine formulated as quadrivalent virus-like particles (QVLP) in Canada.

Methods

Using Monte Carlo simulations, the number of influenza cases, general practitioner visits, inpatient admissions, intensive care unit (ICU) admissions, and deaths due to influenza-associated illness were estimated under no vaccination, plant-derived QVLP vaccines only, or egg-derived vaccines only. The base case analysis examined the adult Canadian population in two subgroups: 18-64 years of age during the 2017/18 season and 65+ years of age during the 2018/19 season. Efficacy data were obtained from QVLP clinical trials. Vaccine effectiveness data for egg-derived vaccines

SUBMITTER: Ramjee L 

PROVIDER: S-EPMC8437550 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature