Associations of maternal bisphenol urine concentrations during pregnancy with neonatal metabolomic profiles.

ABSTRACT:

Background

Fetal exposure to bisphenols is associated with altered fetal growth, adverse birth outcomes and childhood cardio-metabolic risk factors. Metabolomics may serve as a tool to identify the mechanisms underlying these associations. We examined the associations of maternal bisphenol urinary concentrations in pregnancy with neonatal metabolite profiles from cord blood.

Methods

In a population-based prospective cohort study among 225 mother-child pairs, maternal urinary bisphenol A, S and F concentrations in first, second and third trimester were measured. LC-MS/MS was used to determine neonatal concentrations of amino acids, non-esterified fatty acids (NEFA), phospholipids (PL), and carnitines in cord blood.

Results

No associations of maternal total bisphenol co

SUBMITTER: Blaauwendraad SM 

PROVIDER: S-EPMC8437833 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature