Ruthenium-based PACT agents based on bisquinoline chelates: synthesis, photochemistry, and cytotoxicity.

ABSTRACT: The known ruthenium complex [Ru(tpy)(bpy)(Hmte)](PF₆)₂ ([1](PF₆)₂, where tpy = 2,2':6',2″-terpyridine, bpy = 2,2'-bipyridine, Hmte = 2-(methylthio)ethanol) is photosubstitutionally active but non-toxic to cancer cells even upon light irradiation. In this work, the two analogs complexes [Ru(tpy)(NN)(Hmte)](PF₆)₂, where NN = 3,3'-biisoquinoline (i-biq, [2](PF₆)₂) and di(isoquinolin-3-yl)amine (i-Hdiqa, [3](PF₆)₂), were synthesized and their photochemistry and phototoxicity evaluated to assess their suitability as photoactivated chemotherapy (PACT) agents. The increase of the aromatic surface of [2](PF₆)₂ and [3](PF₆)₂, compared to [1](PF

SUBMITTER: Busemann A 

PROVIDER: S-EPMC8437835 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature