Appetite-regulating hormone trajectories and relationships with fat mass development in term-born infants during the first 6 months of life.

ABSTRACT:

Background

The first 6 months of life are a critical window for adiposity programming. Appetite-regulating hormones (ARH) are involved in food intake regulation and might, therefore, play a role in adiposity programming. Studies examining ARH in early life are limited.

Purpose

To investigate ghrelin, peptide YY (PYY) and leptin until 6 months and associations with fat mass percentage (FM%), infant feeding and human milk macronutrients.

Procedures

In 297 term-born infants (Sophia Pluto Cohort), ghrelin (acylated), PYY and leptin were determined at 3 and 6 months, with FM% measurement by PEAPOD. Exclusive breastfeeding (BF) was classified as BF ≥ 3 months. Human milk macronutrients were analyzed (MIRIS Human Milk Analyzer).

Main findings

Ghrelin increased from 3

SUBMITTER: de Fluiter KS 

PROVIDER: S-EPMC8437841 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature