Protein adsorption/desorption dynamics on Ca-enriched titanium surfaces: biological implications.

ABSTRACT: Calcium ions are used in the development of biomaterials for the promotion of coagulation, bone regeneration, and implant osseointegration. Upon implantation, the time-dependent release of calcium ions from titanium implant surfaces modifies the physicochemical characteristics at the implant-tissue interface and thus, the biological responses. The aim of this study is to examine how the dynamics of protein adsorption on these surfaces change over time. Titanium discs with and without Ca were incubated with human serum for 2 min, 180 min, and 960 min. The layer of proteins attached to the surface was characterised using nLC-MS/MS. The adsorption kinetics was different between materials, revealing an increased adsorption of proteins associated with coagulation and immune responses prior to C

SUBMITTER: Romero-Gavilan F 

PROVIDER: S-EPMC8437886 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature