Multi-platform profiling characterizes molecular subgroups and resistance networks in chronic lymphocytic leukemia.

ABSTRACT: Knowledge of the genomic landscape of chronic lymphocytic leukemia (CLL) grows increasingly detailed, providing challenges in contextualizing the accumulated information. To define the underlying networks, we here perform a multi-platform molecular characterization. We identify major subgroups characterized by genomic instability (GI) or activation of epithelial-mesenchymal-transition (EMT)-like programs, which subdivide into non-inflammatory and inflammatory subtypes. GI CLL exhibit disruption of genome integrity, DNA-damage response and are associated with mutagenesis mediated through activation-induced cytidine deaminase or defective mismatch repair. TP53 wild-type and mutated/deleted cases constitute a transcriptionally uniform entity in GI CLL and show similarly poor progression-free

SUBMITTER: Bloehdorn J 

PROVIDER: S-EPMC8438057 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature