Association between post-treatment circulating biomarkers of inflammation and survival among stage II-III colorectal cancer patients.

ABSTRACT:

Background

Biomarker studies on colorectal cancer (CRC) prognosis are limited to pre-diagnostic or pre-operative measures. Post-treatment biomarkers are not well understood for their associations with CRC survival.

Methods

We included 306 eligible incident stage II-III CRC cases from the population-based Seattle Colon Cancer Family Registry. Concentrations of C-reactive protein (CRP), interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), adiponectin, and leptin were measured using post-treatment plasma samples. Adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for all-cause and CRC-specific mortality were calculated using Cox proportional hazard models.

Results

Elevated levels of CRP, IL-6, MCP-1, and adiponectin were significantly associated

SUBMITTER: Hua X 

PROVIDER: S-EPMC8438064 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature