Association of Maternal Hypothyroidism With Cardiovascular Diseases in the Offspring.

ABSTRACT:

Background

No previous study has examined the effect of maternal hypothyroidism on a broad spectrum of cardiovascular disease (CVD) endpoints in the offspring.

Methods

A nationwide population-based cohort study based on the linkage of several Danish nationwide registries was conducted to explore whether maternal hypothyroidism is associated with offspring's CVD. Altogether 1,041,448 singletons born between the 1st of January 1978 and the 31st of December 1998 were investigated from the age of 8 years to the 31st of December 2016. Exposure was maternal diagnosis of hypothyroidism across lifespan and the outcome of interest was a CVD diagnosis in the offspring. Cox regression models were performed to estimate the hazard ratios (HRs) of CVD.

Results

Offspring born to mot

SUBMITTER: Miao M 

PROVIDER: S-EPMC8438132 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature