The Role of rDNA Clusters in Global Epigenetic Gene Regulation.

ABSTRACT: The regulation of gene expression has been studied for decades, but the underlying mechanisms are still not fully understood. As well as local and distant regulation, there are specific mechanisms of regulation during development and physiological modulation of gene activity in differentiated cells. Current research strongly supports a role for the 3D chromosomal structure in the regulation of gene expression. However, it is not known whether the genome structure reflects the formation of active or repressed chromosomal domains or if these structures play a primary role in the regulation of gene expression. During early development, heterochromatinization of ribosomal DNA (rDNA) is coupled with silencing or activation of the expression of different sets of genes. Although the mechanisms be

SUBMITTER: Tchurikov NA 

PROVIDER: S-EPMC8438155 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature