Unexpected details regarding nosocomial transmission revealed by whole-genome sequencing of severe acute respiratory coronavirus virus 2 (SARS-CoV-2).

ABSTRACT:

Objective

Effective infection prevention and control (IPC) measures are key for protecting patients from nosocomial infections and require knowledge of transmission mechanisms in different settings. We performed a detailed outbreak analysis of the transmission and outcome of coronavirus disease 2019 (COVID-19) in a geriatric ward by combining whole-genome sequencing (WGS) with epidemiological data.

Design

Retrospective cohort study.

Setting

Tertiary-care hospital.

Participants

Patients and healthcare workers (HCWs) from the ward with a nasopharyngeal sample (NPS) positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2) RNA during the outbreak period.

Methods

Patient data regarding clinical characteristics, exposure and outcome were collecte

SUBMITTER: Myhrman S 

PROVIDER: S-EPMC8438423 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature