COL4A1 as a novel oncogene associated with the clinical characteristics of malignancy predicts poor prognosis in glioma.

ABSTRACT: Studies have indicated that collagen α-1 (IV) chain (COL4A1) has an indispensable regulatory role in the complex pathological mechanisms of numerous types of malignant tumor. However, its role in the development of glioma has remained elusive. Therefore, the present study sought to determine the association between the expression levels of COL4A1 and the clinical characteristics of gliomas by analyzing large samples. First, analysis of thousands of glioma tissue samples collected from the Gene expression profiling interactive analysis, Gene Expression Omnibus database, the Ivy glioblastoma atlas, The Human Protein Atlas, Chinese Glioma Genome Atlas and The Cancer Genome Atlas. In addition, glioma tissues and normal brain tissues from patients with glioma and epilepsy undergoing surgical re

SUBMITTER: Wang H 

PROVIDER: S-EPMC8438660 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature