Enantioselective vinylogous-Mukaiyama-type dearomatisation by anion-binding catalysis.

ABSTRACT: The first enantioselective vinylogous Mukaiyama-type dearomatisation of heteroarenes under anion-binding catalysis is presented. A recyclable tetrakistriazole catalyst was used for the enantiocontrol of the remote vinylogous active position of silyl dienol ethers. This approach provided chiral heterocycles bearing α,β-unsaturated chains with complete regioselectivity and excellent enantioselectivities (up to 97.5 : 2.5 e.r.).

SUBMITTER: Kaur K 

PROVIDER: S-EPMC8438702 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature