The Role of Age on Beta-Amyloid_1-42 Plasma Levels in Healthy Subjects.

ABSTRACT: Beta-amyloid (Aβ) plaques have been observed in the brain of healthy elderlies with frequencies strongly influenced by age. The aim of the study is to evaluate the role of age and other biochemical and hematological parameters on Aβ_1-42 plasma levels in cognitively and neurologically normal individuals. Two-hundred and seventy-five normal subjects stratified by age groups (<35 years, 35-65 years, and >65 years) were included in the study. Aβ_1-42 plasma levels significantly correlated with age (r_s = 0.27; p < 0.0001) in the whole sample, inversely correlated with age in the first age group (r_s = -0.25, p = 0.01), positively correlated in the second group (r_s = 0.22, p = 0.03), while there was no

SUBMITTER: Zecca C 

PROVIDER: S-EPMC8438760 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature