Meta-analysis of structural MRI studies in anorexia nervosa and the role of recovery: a systematic review protocol.

ABSTRACT:

Background

Anorexia nervosa (AN) is associated with structural brain abnormalities. Studies have reported less cerebral tissue and more cerebrospinal fluid (CSF) in individuals with AN relative to healthy controls, although findings are variable and inconsistent due to variations in sample size, age, and disease state (e.g., active AN, weight-recovered AN). Further, it remains unclear if structural brain abnormalities observed in AN are a consequence of specific brain pathologies or malnutrition, as very few longitudinal neuroimaging studies in AN have been completed.

Methods

To overcome this issue, this comprehensive meta-analysis will combine region-of-interest (ROI) and voxel-based morphometry (VBM) approaches to understand how regional and global structural brain abnorma

SUBMITTER: Dreier MJ 

PROVIDER: S-EPMC8438886 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature