Gut microbial determinants of clinically important improvement in patients with rheumatoid arthritis.

ABSTRACT:

Background

Rapid advances in the past decade have shown that dysbiosis of the gut microbiome is a key hallmark of rheumatoid arthritis (RA). Yet, the relationship between the gut microbiome and clinical improvement in RA disease activity remains unclear. In this study, we explored the gut microbiome of patients with RA to identify features that are associated with, as well as predictive of, minimum clinically important improvement (MCII) in disease activity.

Methods

We conducted a retrospective, observational cohort study on patients diagnosed with RA between 1988 and 2014. Whole metagenome shotgun sequencing was performed on 64 stool samples, which were collected from 32 patients with RA at two separate time-points approximately 6-12 months apart. The Clinical Disease Activ

SUBMITTER: Gupta VK 

PROVIDER: S-EPMC8439035 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature