LC3B phosphorylation regulates FYCO1 binding and directional transport of autophagosomes.

ABSTRACT: Macroautophagy (hereafter referred to as autophagy) is a conserved process that promotes cellular homeostasis through the degradation of cytosolic components, also known as cargo. During autophagy, cargo is sequestered into double-membrane vesicles called autophagosomes, which are predominantly transported in the retrograde direction to the perinuclear region to fuse with lysosomes, thus ensuring cargo degradation.¹ The mechanisms regulating directional autophagosomal transport remain unclear. The ATG8 family of proteins associates with autophagosome membranes² and plays key roles in autophagy, including the movement of autophagosomes. This is achieved via the association of ATG8 with adaptor proteins like FYCO1, involved in the anterograde transport of autophagosomes

SUBMITTER: Nieto-Torres JL 

PROVIDER: S-EPMC8439105 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature