Quantification of cognitive impairment to characterize heterogeneity of patients at risk of developing Alzheimer's disease dementia.

ABSTRACT:

Introduction

Neuropsychological test scores are limited and standard outcomes may mask the heterogeneity of cognitive impairment. This article presents the calculation and evaluation of six composite scores that quantify domain-specific impairment.

Methods

Parameters for composite scores calculation were learned by performing confirmatory factor analysis in a sample of participants from the Alzheimer's Disease Neuroimaging Initiative database. The obtained scores were evaluated with a separate sample of mild cognitive impairment (MCI) in two automated tasks: unsupervised partition in different subgroups and prediction of progression to dementia for different time windows.

Results

MCI subgroups with distinctive cognitive profiles and risk of progression emerged from cl

SUBMITTER: Giraldo DL 

PROVIDER: S-EPMC8439141 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature