Salidroside protects against ventilation-induced lung injury by inhibiting the expression of matrix metalloproteinase-9.

ABSTRACT:

Context

Salidroside, a compound extracted from Rhodiola rosea L. (Crassulaceae), possesses many beneficial pathological effects.

Objective

To explore the effect of salidroside on ventilator-induced lung endothelial dysfunction in vivo and in vitro.

Materials and methods

In vivo, male ICR mice were divided into sham, ventilation, salidroside, and ventilation plus salidroside groups. The mice were ventilated for 4 h, salidroside (50 mg/kg) was administrated intraperitoneally before ventilation, dexamethasone (Dex) (5 mg/kg) was used as a positive control. In vitro, mouse lung vascular endothelial cells (MLVECs) were treated with salidroside, MMP-9 siRNA, and BAY11-7082 (10 μM), and then exposed to cyclic stretch for 4 h. Afterward, lun

SUBMITTER: Zhang H 

PROVIDER: S-EPMC8439245 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature