Voxel-Wise Linearity Analysis of Increments and Decrements in BOLD Responses in Human Visual Cortex Using a Contrast Adaptation Paradigm.

ABSTRACT: The linearity of BOLD responses is a fundamental presumption in most analysis procedures for BOLD fMRI studies. Previous studies have examined the linearity of BOLD signal increments, but less is known about the linearity of BOLD signal decrements. The present study assessed the linearity of both BOLD signal increments and decrements in the human primary visual cortex using a contrast adaptation paradigm. Results showed that both BOLD signal increments and decrements kept linearity to long stimuli (e.g., 3 s, 6 s), yet, deviated from linearity to transient stimuli (e.g., 1 s). Furthermore, a voxel-wise analysis showed that the deviation patterns were different for BOLD signal increments and decrements: while the BOLD signal increments demonstrated a consistent overestimation pattern, the p

SUBMITTER: Lin Y 

PROVIDER: S-EPMC8439421 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature