The latent tuberculosis cascade-of-care among people living with HIV: A systematic review and meta-analysis.

ABSTRACT:

Background

Tuberculosis preventive therapy (TPT) reduces TB-related morbidity and mortality in people living with HIV (PLHIV). Cascade-of-care analyses help identify gaps and barriers in care and develop targeted solutions. A previous latent tuberculosis infection (LTBI) cascade-of-care analysis showed only 18% of persons in at-risk populations complete TPT, but a similar analysis for TPT among PLHIV has not been completed. We conducted a meta-analysis to provide this evidence.

Methods and findings

We first screened potential articles from a LTBI cascade-of-care systematic review published in 2016. From this study, we included cohorts that reported a minimum of 25 PLHIV. To identify new cohorts, we used a similar search strategy restricted to PLHIV. The search was conducted

SUBMITTER: Bastos ML 

PROVIDER: S-EPMC8439450 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature