Maternal obesity is not associated with placental lipid accumulation in women with high omega-3 fatty acid levels.

ABSTRACT:

Introduction

Placentas of obese women have higher lipid content compared to lean women. We have previously shown that supplementation of overweight and obese women with omega-3 fatty acids decreases placental esterification pathways and total lipid content in a mid-western population (Ohio). We hypothesized that placental lipid accumulation and inflammation would be similar between lean and obese women living in a region of high omega-3 intake, such as Hawaii.

Methods

Fifty-five healthy, normal glucose tolerant women from Honolulu Hawaii, dichotomized based on pre-pregnancy BMI into lean (BMI <25 kg/m², n = 29) and obese (BMI >30 kg/m², n = 26), were recruited at scheduled term cesarean delivery. Maternal plasma DHA levels were analyzed by mass spectrom

SUBMITTER: Alvarado FL 

PROVIDER: S-EPMC8439553 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature