Symmetry breaking meets multisite modification.

ABSTRACT: Multisite modification is a basic way of conferring functionality to proteins and a key component of post-translational modification networks. Additional interest in multisite modification stems from its capability of acting as complex information processors. In this paper, we connect two seemingly disparate themes: symmetry and multisite modification. We examine different classes of random modification networks of substrates involving separate or common enzymes. We demonstrate that under different instances of symmetry of the modification network (invoked explicitly or implicitly and discussed in the literature), the biochemistry of multisite modification can lead to the symmetry being broken. This is shown computationally and consolidated analytically, revealing parameter regions where t

SUBMITTER: Ramesh V 

PROVIDER: S-EPMC8439660 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature