Limiting Acute Kidney Injury Progression In Sepsis: Study Protocol and Trial Simulation.

ABSTRACT:

Objectives

To describe study design considerations and to simulate a trial of biomarker-guided sepsis management aimed to reduce acute kidney injury (acute kidney injury). Tissue inhibitor of metalloproteinases-2 and insulin-like growth factor-binding protein 7, urinary biomarkers of cell-cycle arrest, and indicators of kidney stress can detect acute kidney injury before clinical manifestations. We sought to determine the event rates for acute kidney injury as a function of serial measurements of urinary (tissue inhibitor of metalloproteinases-2)•(insulin-like growth factor-binding protein 7) in patients at risk of sepsis-associated acute kidney injury, so that an escalating series of kidney-sparing sepsis bundles based on international guidelines could be applied.

Design

We

SUBMITTER: Molinari L 

PROVIDER: S-EPMC8439672 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature