Cancer After Pediatric Kidney Transplantation: A Long-term Single-center Experience in Japan.

ABSTRACT:

Background

The cancer incidence, types, and risk factors after pediatric kidney transplantation (KT) have been reported in the United States, Canada, Europe, Australia, and New Zealand. However, no information is available about cancer in pediatric KT recipients in Asian countries.

Methods

Children aged <20 y who underwent initial KT from 1983 to 2016 were analyzed. We compared the cancer incidence with that in the general Japanese population using standardized incidence ratio and examined posttransplant cancer risk using Cox proportional hazards models.

Results

A total of 356 children (median age, 11.7 y; interquartile range, 5.0-17.6) received KT with a follow-up period of 4466 person-years. The median age of cancer onset was 18.5 y (interquartile range, 8.0-32.3),

SUBMITTER: Yabuuchi T 

PROVIDER: S-EPMC8440015 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature