Liver Transplantation for Cholangiocarcinoma: Charting a Path With Lessons Learned From Center Experience.

ABSTRACT:

Background

While liver transplantation (LT) with neoadjuvant chemoradiation is increasingly utilized for the management of unresectable cholangiocarcinoma (CCA), data on post-LT survival are limited.

Methods

We identified 844 patients who underwent LT (2002-2019) for nonincidental (CCA listing) or incidental (CCA on explant, not at listing) CCA in the Scientific Registry of Transplant Recipients. Kaplan-Meier and multivariable proportional hazards regression methods evaluated the effects of patient characteristics, donor type, transplant era (before/after 2010), and center volume (center-level CCALTs/active year) on the risk of graft failure and patient mortality.

Results

One center performed >12 CCALTs/y, and the rest performed ≤4. Five-year graft survival was 50.6%.

SUBMITTER: Ziogas IA 

PROVIDER: S-EPMC8440016 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature