Cognitive decline in older adults: What can we learn from optical coherence tomography (OCT)-based retinal vascular imaging?

ABSTRACT:

Introduction

Accumulated vascular damage contributes to the onset and progression of vascular dementia and possibly to Alzheimer's disease. Here we evaluate the feasibility and utility of using retinal imaging of microvascular markers to identify older adults at risk of cognitive disease.

Methods

The "Eye Determinants of Cognition" (EyeDOC) study recruited a biracial, population-based sample of participants from two sites: Jackson, MS, and Washington Co, MD. Optical coherence tomographic angiography (OCTA) was used to capture vessel density (VD) from a 6 × 6 mm scan of the macula in several vascular layers from 2017 to 2019. The foveal avascular zone (FAZ) area was also estimated. Image quality was assessed by trained graders at a reading center. A neurocognitive battery of

SUBMITTER: Abraham AG 

PROVIDER: S-EPMC8440348 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature