Intrinsically photosensitive retinal ganglion cell-driven pupil responses in patients with traumatic brain injury.

ABSTRACT: Previous findings regarding intrinsically photosensitive retinal ganglion cell (ipRGC) function after traumatic brain injury (TBI) are conflicting. We examined ipRGC-driven pupil responses in civilian TBI and control participants using two pupillography protocols that assessed transient and adaptive properties: (1) a one second (s) long wavelength "red" stimulus (651 nm, 133 cd/m²) and 10 increasing intensities of 1 s short wavelength "blue" stimuli (456 nm, 0.167 to 167 cd/m²) with a 60 s interstimulus interval, and (2) two minutes of 0.1 Hz red stimuli (33 cd/m²), followed by two minutes of 0.1 Hz blue stimuli (16 cd/m²). For Protocol 1, constriction amplitude and the 6 s post illumination pupil response (PIPR) were calculated. For Protocol 2,

SUBMITTER: Mostafa J 

PROVIDER: S-EPMC8440415 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature