Computational modeling of nasal nitric oxide flux from the paranasal sinuses: Validation against human experiment.

ABSTRACT:

Background

Nitric oxide (NO) is important in respiratory physiology and airway defense. Although the paranasal sinuses are the major source of nasal NO, transport dynamics between the sinuses and nasal cavities are poorly understood.

Methods

Exhaled nasal NO tracings were measured in two non-asthmatic subjects (one with allergic rhinitis, one without) using NO analyzer connected via face mask. We subsequently performed computational fluid dynamics NO emission simulations based on individual CT scans and compared to the experimental data.

Results

Simulated exhaled NO tracings match well with experimental data (r > 0.84, p < 0.01) for both subjects, with measured peaks reaching 319.6 ppb in one subject (allergic-rhinitis), and 196.9 ppb in the other. The CFD simulation

SUBMITTER: Spector BM 

PROVIDER: S-EPMC8440472 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature