Hypothalamic control of interoceptive hunger.

ABSTRACT: While energy balance is critical to survival, many factors influence food intake beyond caloric need or "hunger." Despite this, some neurons that drive feeding in mice are routinely referred to as "hunger neurons," whereas others are not. To understand how specific hypothalamic circuits control interoceptive hunger, we trained mice to discriminate fasted from sated periods. We then manipulated three hypothalamic neuronal populations with well-known effects on feeding while mice performed this task. While activation of ARC^AGRP neurons in sated mice caused mice to report being food-restricted, LH^VGAT neuron activation or LH^VGLUT2 neuron inhibition did not. In contrast, LH^VGAT neuron inhibition or LH^VGLUT2 neuron activation in fasted mice

SUBMITTER: Siemian JN 

PROVIDER: S-EPMC8440483 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature