Anticholinergic Medication Burden-Associated Cognitive Impairment in Schizophrenia.

ABSTRACT:

Objective

Many psychotropic medications used to treat schizophrenia have significant anticholinergic properties, which are linked to cognitive impairment and dementia risk in healthy subjects. Clarifying the impact of cognitive impairment attributable to anticholinergic medication burden may help optimize cognitive outcomes in schizophrenia. The aim of this study was to comprehensively characterize how this burden affects functioning across multiple cognitive domains in schizophrenia outpatients.

Methods

Cross-sectional data were analyzed using inferential statistics and exploratory structural equation modeling to determine the relationship between anticholinergic medication burden and cognition. Patients with a diagnosis of schizophrenia or schizoaffective disorder (N=1,120

SUBMITTER: Joshi YB 

PROVIDER: S-EPMC8440496 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature