Estimating direct and indirect genetic effects on offspring phenotypes using genome-wide summary results data.

ABSTRACT: Estimation of direct and indirect (i.e. parental and/or sibling) genetic effects on phenotypes is becoming increasingly important. We compare several multivariate methods that utilize summary results statistics from genome-wide association studies to determine how well they estimate direct and indirect genetic effects. Using data from the UK Biobank, we contrast point estimates and standard errors at individual loci compared to those obtained using individual level data. We show that Genomic structural equation modelling (SEM) outperforms the other methods in accurately estimating conditional genetic effects and their standard errors. We apply Genomic SEM to fertility data in the UK Biobank and partition the genetic effect into female and male fertility and a sibling specific effect. We id

SUBMITTER: Warrington NM 

PROVIDER: S-EPMC8440517 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature