Colocalization analysis of polycystic ovary syndrome to identify potential disease-mediating genes and proteins.

ABSTRACT: Polycystic ovary syndrome (PCOS) is a common complex disease in women with a strong genetic component and downstream consequences for reproductive, metabolic and psychological health. There are currently 19 known PCOS risk loci, primarily identified in women of Han Chinese or European ancestry, and 14 of these risk loci were identified or replicated in a genome-wide association study of PCOS performed in up to 10,074 cases and 103,164 controls of European descent. However, for most of these loci the gene responsible for the association is unknown. We therefore use a Bayesian colocalization approach (Coloc) to highlight genes in PCOS-associated regions that may have a role in mediating the disease risk. We evaluated the posterior probabilities of evidence consistent with shared causal varia

SUBMITTER: Censin JC 

PROVIDER: S-EPMC8440598 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature