An observational and Mendelian randomisation study on vitamin D and COVID-19 risk in UK Biobank.

ABSTRACT: A growing body of evidence suggests that vitamin D deficiency has been associated with an increased susceptibility to viral and bacterial respiratory infections. In this study, we aimed to examine the association between vitamin D and COVID-19 risk and outcomes. We used logistic regression to identify associations between vitamin D variables and COVID-19 (risk of infection, hospitalisation and death) in 417,342 participants from UK Biobank. We subsequently performed a Mendelian Randomisation (MR) study to look for evidence of a causal effect. In total, 1746 COVID-19 cases (399 deaths) were registered between March and June 2020. We found no significant associations between COVID-19 infection risk and measured 25-OHD levels after adjusted for covariates, but this finding is limited by the f

SUBMITTER: Li X 

PROVIDER: S-EPMC8440633 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature