Individualised dosimetry and safety of SIRT for intrahepatic cholangiocarcinoma.

ABSTRACT:

Background

The aim of this study was to investigate the safety and efficacy of selective internal radiation therapy (SIRT) with ⁹⁰Y resin microspheres for the treatment of Intrahepatic Cholangiocarcinoma (ICC). A total of 23 SIRT procedures from 18 ICC subjects were analysed to determine a lesion-based dose/response relationship with absorbed dose measures from ⁹⁰Y PET and metabolic response as measured on [¹⁸F]FDG PET. Average absorbed dose (D_avg), minimum dose to 70% of the volume (D₇₀), volume receiving at least 50 Gy (V₅₀), biological effective dose (BED) and equivalent uniform dose (EUD), were compared to changes in metabolic volume, maximum standardised uptake value (SUV_max) and total lesion glycolys

SUBMITTER: Willowson KP 

PROVIDER: S-EPMC8440713 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature