Glycosaminoglycan biosynthesis pathway in host genome is associated with Helicobacter pylori infection.

ABSTRACT: Helicobacter pylori is a causative pathogen of many gastric and extra-gastric diseases. It has infected about half of the global population. There were no genome-wide association studies (GWAS) for H. pylori infection conducted in Chinese population, who carried different and relatively homogenous strain of H. pylori. In this work, we performed SNP (single nucleotide polymorphism)-based, gene-based and pathway-based genome-wide association analyses to investigate the genetic basis of host susceptibility to H. pylori infection in 480 Chinese individuals. We also profiled the composition and function of the gut microbiota between H. pylori infection cases and controls. We found several genes and pathways associated with H. pylori infection (P < 0.05), replicated one previously reported SNP r

SUBMITTER: Hu D 

PROVIDER: S-EPMC8440747 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature