Proteomic Analysis of Cardiac Adaptation to Exercise by High Resolution Mass Spectrometry.

ABSTRACT: Regular exercise has many health benefits, among which is a significant reduction of cardiovascular risk. Although many beneficial effects of exercise are well described, the exact mechanisms by which exercise confers cardiovascular benefits are yet to be fully understood. In the current study, we have used high resolution mass spectrometry to determine the proteomic responses of the heart to exercise training in mice. The impact of exercise-induced oxidative stress on modifications of cardiomyocyte proteins with lipid peroxidation biomarker 4-hydroxynonenal (4-HNE) was examined as well. Fourteen male mice were randomized into the control (sedentary) group and the exercise group that was subjected to a swim exercise training program for 5 days a week for 5 months. Proteins were isolated fr

SUBMITTER: Al-Menhali AS 

PROVIDER: S-EPMC8440823 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature