Antitumoral Action of Resveratrol Through Adenosinergic Signaling in C6 Glioma Cells.

ABSTRACT: Gliomas are the most common and aggressive primary tumors in the central nervous system. The nucleoside adenosine is considered to be one major constituent within the tumor microenvironment. The adenosine level mainly depends on two enzymatic activities: 5'-nucleotidase (5'NT or CD73) that synthesizes adenosine from AMP, and adenosine deaminase (ADA) that converts adenosine into inosine. Adenosine activates specific G-protein coupled receptors named A₁, A_2A, A_2B, and A₃ receptors. Resveratrol, a natural polyphenol present in grapes, peanuts, and berries, shows several healthy effects, including protection against cardiovascular, endocrine, and neurodegenerative diseases and cancer. However, the molecular mechanisms of resveratrol actions are not

SUBMITTER: Sanchez-Melgar A 

PROVIDER: S-EPMC8440868 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature