Schistosome AMPK Is Required for Larval Viability and Regulates Glycogen Metabolism in Adult Parasites.

ABSTRACT: On entering the mammalian host, schistosomes transition from a freshwater environment where resources are scarce, to an environment where there is an unlimited supply of glucose, their preferred energy substrate. Adult schistosome glycolytic activity consumes almost five times the parasite's dry weight in glucose per day to meet the parasite's energy demands, and the schistosome glycolytic enzymes and mechanisms for glucose uptake that sustain this metabolic activity have previously been identified. However, little is known of the parasite processes that regulate schistosome glucose metabolism. We previously described the Schistosoma mansoni ortholog of 5' AMP-Activated Protein Kinase (AMPK), which is a central regulator of energy metabolism in eukaryotes, and characterized the deve

SUBMITTER: Hunter KS 

PROVIDER: S-EPMC8440919 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature