Two New Diterpenoids from Biscogniauxia sp. and Their Activities.

ABSTRACT: Two new diterpenoids, including a seco-isopimarane type (1) and an abietane type (2), were isolated from Biscogniauxia sp. (71-10-1-1). Their structures, including absolute configurations, were elucidated by NMR spectroscopic analyses, X-ray crystallography, ¹³C chemical shifts calculations, and ECD calculations. This is the first report of diterpenoids from Biscogniauxia sp. Furthermore, short-term memory enhancement against Alzheimer's disease (AD), anti-inflammatory, and cytotoxic activities of 1-2 were also evaluated. The results showed that compound 1 exhibited short-term memory enhancement activity against AD.

SUBMITTER: Zhao H 

PROVIDER: S-EPMC8440928 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature