Hyperleukocytosis-induced stroke and tonsillar herniation: Case report.

ABSTRACT:

Introduction

and Importance: Acute ischemic stroke is a rare event in children with leukemia, yet with long-term morbidity, substantial health, and economic cost. Central nervous system (CNS) leukemic involvement and chemotherapy-related stroke are the most common causes. Hyperleukocytosis induced stroke is very rarely reported.

Case presentation

A 2-year-old male child presented with hyperleukocytosis (leukocyte count was 320x10⁹/L). Bone marrow evaluation revealed T-cell acute lymphoblastic leukemia. He was treated with dexamethasone, vincristine and daunorubicin, and on day 4 of chemotherapy, he developed abnormal movements, altered mental status, limb weakness and mutism. Magnetic resonance imaging of the brain showed multifocal infarctions involving left pons

SUBMITTER: Hashem H 

PROVIDER: S-EPMC8441068 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature