Ontology highlight
ABSTRACT:
SUBMITTER: Huang Y
PROVIDER: S-EPMC8441146 | biostudies-literature | 2021 Sep
REPOSITORIES: biostudies-literature
Huang Yepei Y Bai Xue X Guo Zhenchang Z Dong Hanyang H Fu Yun Y Zhang Hui H Zhai Guijin G Tian Shanshan S Wang Ye Y Zhang Kai K
iScience 20210828 9
Chemical modification on mRNA can recruit specific binding proteins (readers/partners) to determine post-transcriptional gene regulation. However, the identification of the reader is extremely limited owing to the rather weak and highly dynamic non-covalent interactions between mRNA modification and reader, and therefore the sensitive and robust approaches are desirable. Here, we report a DNA-guided photoactivatable-based chemical proteomic approach for profiling the readers of mRNA methylation. ...[more]